Inhibitors | Comment | Organism | Structure |
---|---|---|---|
calf thymus histone H2B | growth inhibitory activity against bacterial gene expressing Escherichia coli with calculated 50% growth inhibitory concentrations of 3.8 microM. Histone H2B penetrates the cell membrane of JCM5491 OmpT+ cells | Escherichia coli | |
calf thymus histone H3 | growth inhibitory activity against bacterial gene expressing Escherichia coli with calculated 50% growth inhibitory concentrations of 10 microM. Histones H3 and H4 remain on the cell surface and subsequently disrupt the cell membrane structure with bleb formation in a manner similar to general antimicrobial peptides | Escherichia coli | |
calf thymus histone H4 | growth inhibitory activity against bacterial gene expressing Escherichia coli with calculated 50% growth inhibitory concentrations of 12.7 microM. Histones H3 and H4 remain on the cell surface and subsequently disrupt the cell membrane structure with bleb formation in a manner similar to general antimicrobial peptides | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Escherichia coli JCM 5491 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
calf thymus histone H2B + H2o | - |
Escherichia coli | ? | strong fragmentation of histone H2B | ? | |
calf thymus histone H2B + H2o | - |
Escherichia coli JCM 5491 | ? | strong fragmentation of histone H2B | ? | |
calf thymus histone H3 + H2o | - |
Escherichia coli | ? | moderate fragmentation of histone H3 | ? | |
calf thymus histone H3 + H2o | - |
Escherichia coli JCM 5491 | ? | moderate fragmentation of histone H3 | ? | |
calf thymus histone H4 + H2o | - |
Escherichia coli | ? | slight fragmentation of histone H4 | ? | |
calf thymus histone H4 + H2o | - |
Escherichia coli JCM 5491 | ? | slight fragmentation of histone H4 | ? |
General Information | Comment | Organism |
---|---|---|
physiological function | OmpT is involved in the antimicrobial properties of Arg- and Lys-rich histones and the modes of antimicrobial action of these histones are different | Escherichia coli |