Crystallization (Comment) | Organism |
---|---|
crystal structure of Met205Ser mutant enzyme in complex with the two inhibitors rs367 and rs370, crystals are grown at 293 K by vapor diffusion in hanging drops | Plasmodium falciparum |
Protein Variants | Comment | Organism |
---|---|---|
M205S | mutant enzyme with reduced chances of autolysis during purification | Plasmodium falciparum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
pepstatin A | - |
Plasmodium falciparum | |
rs367 | - |
Plasmodium falciparum | |
rs370 | - |
Plasmodium falciparum |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
vacuole | food vacuole | Plasmodium falciparum | 5773 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Hemoglobin + H2O | Plasmodium falciparum | the enzyme initiates degradation of hemoglobin by cleavage at the alpha-chain between Phe33 and Leu34 | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | P46925 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Hemoglobin + H2O | the enzyme initiates degradation of hemoglobin by cleavage at the alpha-chain between Phe33 and Leu34 | Plasmodium falciparum | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | - |
Plasmodium falciparum |