Application | Comment | Organism |
---|---|---|
medicine | design of a selective and potent inhibitor is crucial since aspartic proteinases known to be involved in many diseases such as cancer and malaria | Rhizopus sp. |
Cloned (Comment) | Organism |
---|---|
- |
Rhizopus sp. |
Crystallization (Comment) | Organism |
---|---|
chimeric enzymes, containing domains of porcine pepsinogen | Rhizopus sp. |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ac-NA-Nva-3-hydroxy 4-amino 6-methyl heptanoic acid-Nva-NA-amide | - |
Rhizopus sp. | |
Ac-NA-Nva-3-hydroxy 4-amino 6-methyl heptanoyl-Nva-NA-amide | - |
Rhizopus sp. | |
Ac-NA-Val-3-hydroxy 4-amino 6-methyl heptanoic acid-2-aminobutanoyl-NA-amide | - |
Rhizopus sp. | |
Ac-NA-Val-3-hydroxy 4-amino 6-methyl heptanoyl-Abu-NA-amide | - |
Rhizopus sp. | |
pepstatin A | - |
Rhizopus sp. |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.002 | - |
KPIEF p-nitrophenylalanine-RL | pH 3.0, 37°C | Rhizopus sp. | |
0.003 | - |
KPIDF p-nitrophenylalanine-RL | pH 3.0, 37°C | Rhizopus sp. | |
0.003 | - |
KPISF p-nitrophenylalanine-RL | pH 3.0, 37°C | Rhizopus sp. | |
0.004 | - |
KPALF p-nitrophenylalanine-RL | pH 3.0, 37°C | Rhizopus sp. | |
0.004 | - |
KPLEF p-nitrophenylalanine-RL | pH 3.0, 37°C | Rhizopus sp. | |
0.006 | - |
KPIAF p-nitrophenylalanine-RL | pH 3.0, 37°C | Rhizopus sp. | |
0.006 | - |
KPILF p-nitrophenylalanine-RL | pH 3.0, 37°C | Rhizopus sp. | |
0.006 | - |
KAIEF p-nitrophenylalanine-RL | pH 3.0, 37°C | Rhizopus sp. | |
0.007 | - |
KPSEF p-nitrophenylalanine-RL | pH 3.0, 37°C | Rhizopus sp. | |
0.007 | - |
KLIEF p-nitrophenylalanine-RL | pH 3.0, 37°C | Rhizopus sp. | |
0.008 | - |
KPAEF p-nitrophenylalanine-RL | pH 3.0, 37°C | Rhizopus sp. | |
0.008 | - |
KPREF p-nitrophenylalanine-RL | pH 3.0, 37°C | Rhizopus sp. | |
0.009 | - |
KSIEF p-nitrophenylalanine-RL | pH 3.0, 37°C | Rhizopus sp. | |
0.01 | - |
KPDEF p-nitrophenylalanine-RL | pH 3.0, 37°C | Rhizopus sp. | |
0.013 | - |
KPALF p-nitrophenylalanine-RL | pH 3.0, 37°C, chimeric enzyme | Rhizopus sp. | |
0.047 | - |
KPISF p-nitrophenylalanine-RL | pH 3.0, 37°C, chimeric enzyme | Rhizopus sp. | |
0.056 | - |
KPILF p-nitrophenylalanine-RL | pH 3.0, 37°C, chimeric enzyme | Rhizopus sp. | |
0.057 | - |
KPIEF p-nitrophenylalanine-RL | pH 3.0, 37°C, chimeric enzyme | Rhizopus sp. | |
0.065 | - |
KPDEF p-nitrophenylalanine-RL | pH 3.0, 37°C, chimeric enzyme | Rhizopus sp. | |
0.089 | - |
KPAEF p-nitrophenylalanine-RL | pH 3.0, 37°C, chimeric enzyme | Rhizopus sp. | |
0.101 | - |
KPLEF p-nitrophenylalanine-RL | pH 3.0, 37°C, chimeric enzyme | Rhizopus sp. | |
0.108 | - |
KPSEF p-nitrophenylalanine-RL | pH 3.0, 37°C, chimeric enzyme | Rhizopus sp. | |
0.139 | - |
KLIEF p-nitrophenylalanine-RL | pH 3.0, 37°C, chimeric enzyme | Rhizopus sp. | |
0.157 | - |
KPIAF p-nitrophenylalanine-RL | pH 3.0, 37°C, chimeric enzyme | Rhizopus sp. | |
0.21 | - |
KSIEF p-nitrophenylalanine-RL | pH 3.0, 37°C, chimeric enzyme | Rhizopus sp. | |
0.211 | - |
KPIDF p-nitrophenylalanine-RL | pH 3.0, 37°C, chimeric enzyme | Rhizopus sp. | |
0.269 | - |
KAIEF p-nitrophenylalanine-RL | pH 3.0, 37°C, chimeric enzyme | Rhizopus sp. |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rhizopus sp. | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
KAIEF p-nitrophenylalanine-RL + H2O | - |
Rhizopus sp. | KAIEF + p-nitrophenylalanine-RL | - |
? | |
KLIEF p-nitrophenylalanine-RL + H2O | - |
Rhizopus sp. | KLIEF + p-nitrophenylalanine-RL | - |
? | |
KPAEF p-nitrophenylalanine-RL + H2O | - |
Rhizopus sp. | KPAEF + p-nitrophenylalanine-RL | - |
? | |
KPALF p-nitrophenylalanine-RL + H2O | - |
Rhizopus sp. | KPALF + p-nitrophenylalanine-RL | - |
? | |
KPDEF p-nitrophenylalanine-RL + H2O | - |
Rhizopus sp. | KPDEF + p-nitrophenylalanine-RL | - |
? | |
KPIAF p-nitrophenylalanine-RL + H2O | - |
Rhizopus sp. | KPIAF + p-nitrophenylalanine-RL | - |
? | |
KPIDF p-nitrophenylalanine-RL + H2O | - |
Rhizopus sp. | KPIDF + p-nitrophenylalanine-RL | - |
? | |
KPIEF p-nitrophenylalanine-RL + H2O | - |
Rhizopus sp. | KPIEF + p-nitrophenylalanine-RL | - |
? | |
KPILF p-nitrophenylalanine-RL + H2O | - |
Rhizopus sp. | KPILF + p-nitrophenylalanine-RL | - |
? | |
KPISF p-nitrophenylalanine-RL + H2O | - |
Rhizopus sp. | KPISF + p-nitrophenylalanine-RL | - |
? | |
KPLEF p-nitrophenylalanine-RL + H2O | - |
Rhizopus sp. | KPLEF + p-nitrophenylalanine-RL | - |
? | |
KPREF p-nitrophenylalanine-RL + H2O | - |
Rhizopus sp. | KPREF + p-nitrophenylalanine-RL | - |
? | |
KPSEF p-nitrophenylalanine-RL + H2O | - |
Rhizopus sp. | KPSEF + p-nitrophenylalanine-RL | - |
? | |
KSIEF p-nitrophenylalanine-RL + H2O | - |
Rhizopus sp. | KSIEF + p-nitrophenylalanine-RL | - |
? | |
Lys-Pro-Ala-Lys-Phe-(NO2)Phe-Arg-Leu + H2O | - |
Rhizopus sp. | Lys-Pro-Ala-Lys-Phe + (NO2)Phe-Arg-Leu | - |
? | |
Lys-Pro-Ile-Glu-Phe-(NO2)Phe-Arg-Leu + H2O | - |
Rhizopus sp. | Lys-Pro-Ile-Glu-Phe + (NO2)Phe-Arg-Leu | - |
? |
Synonyms | Comment | Organism |
---|---|---|
rhizopuspepsinogen | - |
Rhizopus sp. |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.23 | - |
KPILF p-nitrophenylalanine-RL | pH 3.0, 37°C | Rhizopus sp. | |
0.77 | - |
KPIDF p-nitrophenylalanine-RL | pH 3.0, 37°C | Rhizopus sp. | |
1.8 | - |
KSIEF p-nitrophenylalanine-RL | pH 3.0, 37°C | Rhizopus sp. | |
3 | - |
KPISF p-nitrophenylalanine-RL | pH 3.0, 37°C | Rhizopus sp. | |
3 | - |
KPIAF p-nitrophenylalanine-RL | pH 3.0, 37°C | Rhizopus sp. | |
3 | - |
KPILF p-nitrophenylalanine-RL | pH 3.0, 37°C, chimeric enzyme | Rhizopus sp. | |
3 | - |
KPDEF p-nitrophenylalanine-RL | pH 3.0, 37°C, chimeric enzyme | Rhizopus sp. | |
4 | - |
KPISF p-nitrophenylalanine-RL | pH 3.0, 37°C, chimeric enzyme | Rhizopus sp. | |
5 | - |
KAIEF p-nitrophenylalanine-RL | pH 3.0, 37°C | Rhizopus sp. | |
5 | - |
KLIEF p-nitrophenylalanine-RL | pH 3.0, 37°C | Rhizopus sp. | |
5 | - |
KPIDF p-nitrophenylalanine-RL | pH 3.0, 37°C, chimeric enzyme | Rhizopus sp. | |
6 | - |
KPIEF p-nitrophenylalanine-RL | pH 3.0, 37°C | Rhizopus sp. | |
6 | - |
KPSEF p-nitrophenylalanine-RL | pH 3.0, 37°C, chimeric enzyme | Rhizopus sp. | |
6.08 | - |
KPIDF p-nitrophenylalanine-RL | pH 3.0, 37°C | Rhizopus sp. | |
7 | - |
KPSEF p-nitrophenylalanine-RL | pH 3.0, 37°C | Rhizopus sp. | |
7 | - |
KPLEF p-nitrophenylalanine-RL | pH 3.0, 37°C, wild-type and chimeric enzyme | Rhizopus sp. | |
8 | - |
KPDEF p-nitrophenylalanine-RL | pH 3.0, 37°C | Rhizopus sp. | |
9 | - |
KPALF p-nitrophenylalanine-RL | pH 3.0, 37°C | Rhizopus sp. | |
13 | - |
KPALF p-nitrophenylalanine-RL | pH 3.0, 37°C, chimeric enzyme | Rhizopus sp. | |
13 | - |
KSIEF p-nitrophenylalanine-RL | pH 3.0, 37°C, chimeric enzyme | Rhizopus sp. | |
17 | - |
KPIAF p-nitrophenylalanine-RL | pH 3.0, 37°C, chimeric enzyme | Rhizopus sp. | |
18 | - |
KPREF p-nitrophenylalanine-RL | pH 3.0, 37°C | Rhizopus sp. | |
21 | - |
KPAEF p-nitrophenylalanine-RL | pH 3.0, 37°C, chimeric enzyme | Rhizopus sp. | |
22 | - |
KPAEF p-nitrophenylalanine-RL | pH 3.0, 37°C | Rhizopus sp. | |
38 | - |
KLIEF p-nitrophenylalanine-RL | pH 3.0, 37°C, chimeric enzyme | Rhizopus sp. | |
41 | - |
KPIEF p-nitrophenylalanine-RL | pH 3.0, 37°C, chimeric enzyme | Rhizopus sp. | |
46 | - |
KAIEF p-nitrophenylalanine-RL | pH 3.0, 37°C, chimeric enzyme | Rhizopus sp. |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
3 | - |
- |
Rhizopus sp. |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000006 | - |
pepstatin A | pH 3.0, 37°C | Rhizopus sp. | |
0.0000029 | - |
Ac-NA-Val-3-hydroxy 4-amino 6-methyl heptanoic acid-2-aminobutanoyl-NA-amide | pH 3.0, 37°C | Rhizopus sp. | |
0.000077 | - |
Ac-NA-Nva-3-hydroxy 4-amino 6-methyl heptanoic acid-Nva-NA-amide | pH 3.0, 37°C | Rhizopus sp. |