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Literature summary for 3.4.23.16 extracted from
- Systematic profiling of substrate binding response to multidrug-resistant mutations in HIV-1 protease Implication for combating drug resistance (2017), J. Mol. Graph. Model., 74, 83-88 .
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| D29N | the mutation can largely reduce the binding capability of the two peptides ARVLAEAM and NLAFPQGE as compared to the wild type enzyme | Human immunodeficiency virus 1 |
| I54V | the mutant enzyme is resistant against inhibition by darunavir and nelfinavir | Human immunodeficiency virus 1 |
| L10I | the mutant enzyme is resistant against inhibition by darunavir and tipranavir | Human immunodeficiency virus 1 |
| L90M | the mutant enzyme is resistant against inhibition by darunavir and tipranavir | Human immunodeficiency virus 1 |
| M46L | the mutant enzyme is resistant against inhibition by darunavir and saquinavir | Human immunodeficiency virus 1 |
| N25D | the mutation completely eliminates the binding capability of the two peptides ARVLAEAM and NLAFPQGE as compared to the wild type enzyme | Human immunodeficiency virus 1 |
| V82T | the mutant enzyme is resistant against inhibition by darunavir | Human immunodeficiency virus 1 |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| atazanavir | - |
Human immunodeficiency virus 1 |  |
| darunavir | - |
Human immunodeficiency virus 1 | |
| fosamprenavir | - |
Human immunodeficiency virus 1 | |
| indinavir | - |
Human immunodeficiency virus 1 | |
| lopinavir | - |
Human immunodeficiency virus 1 | |
| nelfinavir | - |
Human immunodeficiency virus 1 | |
| saquinavir | - |
Human immunodeficiency virus 1 | |
| tipranavir | - |
Human immunodeficiency virus 1 | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Gag polyprotein + H2O | Human immunodeficiency virus 1 | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Human immunodeficiency virus 1 | Q7SSI0 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| AETFYVDG + H2O | - |
Human immunodeficiency virus 1 | AETF + YVDG | - |
? | |
| ARVLAEAM + H2O | - |
Human immunodeficiency virus 1 | ARVL + AEAM | - |
? | |
| ATIMMQRG + H2O | - |
Human immunodeficiency virus 1 | ATIM + MQRG | - |
? | |
| DCAWLEAQ + H2O | - |
Human immunodeficiency virus 1 | DCAW + LEAQ | - |
? | |
| Gag polyprotein + H2O | - |
Human immunodeficiency virus 1 | ? | - |
? | |
| NLAFPQGE + H2O | - |
Human immunodeficiency virus 1 | NLAF + PQG | - |
? | |
| PGNFLQSR + H2O | - |
Human immunodeficiency virus 1 | PGNF + LQSR | - |
? | |
| RKVLFLDG + H2O | - |
Human immunodeficiency virus 1 | RKVL + FLDG | - |
? | |
| RQANFLGK + H2O | - |
Human immunodeficiency virus 1 | RQAN + FLGK | - |
? | |
| RQANFLRE + H2O | - |
Human immunodeficiency virus 1 | RQAN + FLRE | - |
? | |
| SQNYPIVQ + H2O | - |
Human immunodeficiency virus 1 | SQNY + PIVQ | - |
? | |
| TLNFPISP + H2O | - |
Human immunodeficiency virus 1 | TLNF + PISP | - |
? | |
| TLNFPQIT + H2O | - |
Human immunodeficiency virus 1 | TLNF + PQIT | - |
? | |
| TNIMMQKS + H2O | - |
Human immunodeficiency virus 1 | TNIM + MQKS | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HIV-1 PR | - |
Human immunodeficiency virus 1 |
| HIV-1 protease | - |
Human immunodeficiency virus 1 |
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