Literature summary for 3.4.22.B70 extracted from

Ma, C.; Wu, B.; Huang, X.; Yuan, Z.; Nong, K.; Dong, B.; Bai, Y.; Zhu, H.; Wang, W.; Ai, K.
SUMO-specific protease 1 regulates pancreatic cancer cell proliferation and invasion by targeting MMP-9 (2014), Tumour Biol., 35, 12729-12735.

Search for more literature for 3.4.22.B70

Application

Application	Comment	Organism
diagnostics	SENP1 may serve as a potential diagnostic and therapeutic target of pancreatic ductal adenocarcinoma	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
quantitative real-time PCR expression analysis	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nucleus	-	Homo sapiens	5634	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
pancreatic ductal adenocarcinoma cell	enzyme SENP1 is upregulated in pancreatic ductal adenocarcinoma tissues compared with adjacent normal tissues	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
SENP1	-	Homo sapiens
SUMO-specific protease	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	knockdown of SENP1 by SENP1-siRNA inhibits pancreatic cancer cell proliferation, migration, and invasion. Silencing of SENP1 results in downregulation of MMP-9, which is pivotal for PDAC cell growth and migration	Homo sapiens
physiological function	SUMO-specific protease 1 regulates pancreatic cancer cell proliferation and invasion by targeting MMP-9. Enzyme SENP1 is positively associated with lymph node metastasis and TNM stage	Homo sapiens

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Release 2023.1 (January 2023)