Literature summary for 3.4.22.B69 extracted from

Akhter, M.; Saha, R.; Tanwar, O.; Mumtaz Alam, M.; Zaman, M.
Synthesis and antimalarial activity of quinoline-substituted furanone derivatives and their identification as selective falcipain-2 inhibitors (2015), Med. Chem. Res., 24, 879-890 .

No PubMed abstract available

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Crystallization (Commentary)

Crystallization (Comment)	Organism
molecular docking of inhibitors	Plasmodium falciparum

Inhibitors

Inhibitors	Comment	Organism	Structure
3-((2-chloro-6-methoxyquinolin-3-yl)methylene)-5-(2,4-dimethylphenyl)furan-2(3H)-one	IC50 value on parasite 0.50 microg/ml	Plasmodium falciparum
3-((2-chloro-6-methoxyquinolin-3-yl)methylene)-5-(4-chlorophenyl)furan-2(3H)-one	IC50 value on parasite 0.61 micro/ml	Plasmodium falciparum

Organism

Organism	UniProt	Comment	Textmining
Plasmodium falciparum	Q9N6S8	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O	-	Plasmodium falciparum	benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin	-	?

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Release 2023.1 (January 2023)