Application | Comment | Organism |
---|---|---|
medicine | there may be a connection between a defect in SUMO-1 conjugation to the PML protein and acute promyelocytic leukemia (ALP). Specific Ulp inhibitors can therefore have therapeutic value for ALP | Saccharomyces cerevisiae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | there may be a connection between a defect in SUMO-1 conjugation to the PML protein and acute promyelocytic leukemia (ALP). Specific Ulp inhibitors can therefore have therapeutic value for ALP | Saccharomyces cerevisiae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
SUMO-1 protein + H2O | Saccharomyces cerevisiae | the enzyme plays an essential role in the G2/M phase of the cell cycle | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | Q02724 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
His6-Smt3-hemagglutinin fusion protein + H2O | - |
Saccharomyces cerevisiae | ? | - |
? | |
His6-Smt3-Leu-beta-galactosidase + H2O | - |
Saccharomyces cerevisiae | ? | - |
? | |
His6-Smt3-Met-beta-galactosidase + H2O | - |
Saccharomyces cerevisiae | ? | - |
? | |
SUMO-1 protein + H2O | - |
Saccharomyces cerevisiae | ? | - |
? | |
SUMO-1 protein + H2O | the enzyme plays an essential role in the G2/M phase of the cell cycle | Saccharomyces cerevisiae | ? | - |
? |