Literature summary for 3.4.22.63 extracted from

Guo, W.; Dong, A.; Pan, X.; Lin, X.; Lin, Y.; He, M.; Zhu, B.; Jin, L.; Yao, R.
Role of caspase-10 in the death of acute leukemia cells (2016), Oncol. Lett., 12, 1623-1629 .

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Application

Application	Comment	Organism
medicine	in HL-60 cells that are treated with chemotherapy drugs combined with a caspase-10 inhibitor, the rate of survival decreases significantly compared with HL?60 cells treated with chemotherapy drugs alone. The rate of survival of Jurkat cells treated with chemotherapy drugs combined with the caspase-10 inhibitor increases significantly compared with Jurkat cells treated with chemotherapy drugs alone. Caspase-10 may be associated with autophagy in acute myeloid leukemia cells, but not in acute lymphatic leukemia cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q92851	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HL-60 cell	-	Homo sapiens	-
JURKAT cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)