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Literature summary for 3.4.22.63 extracted from

  • Meng, L.; Sefah, K.; ODonoghue, M.B.; Zhu, G.; Shangguan, D.; Noorali, A.; Chen, Y.; Zhou, L.; Tan, W.
    Silencing of PTK7 in colon cancer cells: caspase-10-dependent apoptosis via mitochondrial pathway (2010), PLoS ONE, 5, e14018.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.63

Activating Compound

Activating Compound Comment Organism Structure
additional information proteolytic activation of caspase-10 is induced in apoptosis Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
the caspase-10 gene is linked to the caspase-8 gene, EC 3.4.22.61, at the human chromosome locus 2q33-34 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Z-AEVD-fluoromethylketone a caspase-10 inhibitor Homo sapiens
Z-VAD-fluoromethylketone a caspase-family inhibitor Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification procaspase-10 is activated to caspase-10. Activation of caspase-10 is induced in apoptosis Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HCT-116 cell
-
 Homo sapiens
-

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

General Information

General Information Comment Organism
malfunction addition of a caspase-10 inhibitor totally blocks PTK7-knockdown-induced apoptosis Homo sapiens
physiological function activation of caspase-10 in apoptosis is induced by PTK7 knockdown. Caspase-10 may play a critical role in PTK7-knockdown-induced apoptosis, downstream of mitochondria. The intrinsic pathway, i.e. mitochondria pathway, involves a decrease in mitochondrial membrane potential and release of cytochrome, overview Homo sapiens