Activating Compound | Comment | Organism | Structure |
---|---|---|---|
adenosine | extracellular adenosine induces apoptosis by activating caspase-9 and caspase-3 in association with mitochondrial damage via A2a adenosine receptors, induction dose-dependent (1-20 mM) and time-dependent (24-72 h) | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | mechanisms of adenosine-induced apoptosis in human colonic cancer cells | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
pro-caspase-3 + H2O | Homo sapiens | mechanisms of adenosine-induced apoptosis in human colonic cancer cells | caspase-3 + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P55211 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Caco-2 cell | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
mechanisms of adenosine-induced apoptosis in human colonic cancer cells, cell viability, DNA laddering, expression analysis of adenosine receptors, overexpression of A2a adenosine receptors, determination of mitochondrial membrane potentials, adenosine disrupts mitochondrial membrane potentials and activates caspase-9 and caspase-3, but not caspase-8 | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-LEHD-7-amido-4-trifluoromethylcoumarin + H2O | i.e. Ac-Leu-Glu-His-Asp-MCA, fluorescence assay, 50 microg cell lysate incubated with 5 microl of 1 mM substrate | Homo sapiens | acetyl-LEHD + 7-amino-4-trifluoromethylcoumarin | - |
? | |
pro-caspase-3 + H2O | mechanisms of adenosine-induced apoptosis in human colonic cancer cells | Homo sapiens | caspase-3 + ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
activity assay at | Homo sapiens |