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Literature summary for 3.4.22.60 extracted from

  • Hashimoto, T.; Yamauchi, L.; Hunter, T.; Kikkawa, U.; Kamada, S.
    Possible involvement of caspase-7 in cell cycle progression at mitosis (2008), Genes Cells, 13, 609-621.
    View publication on PubMed
Search for more literature for 3.4.22.60

Protein Variants

Protein Variants Comment Organism
additional information knockdown of caspase-7 by using siRNAs results in the inhibition of Hep-G2 cell proliferation, but knockdown of other caspases does not show a significant effect on cell growth. The expression of His-tagged shRNA directed against caspase-7 induce the cell cycle arrest at mitosis, which is rescued by the re-expression of caspase-7 containing silent mutations at the target site for the shRNA Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens possible involvement of caspase-7 in cell cycle progression at mitosis, caspases including caspase-3, caspase-7, caspase-8 and caspase-9, are activated during mitosis and are potentially involved in the regulation at M phase. Chemically synthesized caspase inhibitors delay mitotic progression and induce accumulation of mitotic cells, which exhibits abnormal chromatin condensation and incomplete chromosome segregation ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
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 Homo sapiens
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Hep-G2 cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information possible involvement of caspase-7 in cell cycle progression at mitosis, caspases including caspase-3, caspase-7, caspase-8 and caspase-9, are activated during mitosis and are potentially involved in the regulation at M phase. Chemically synthesized caspase inhibitors delay mitotic progression and induce accumulation of mitotic cells, which exhibits abnormal chromatin condensation and incomplete chromosome segregation Homo sapiens ?
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