Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | caspase-3 is activated downstream of the death receptor signaling or via death receptor-independent pathway | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
triptolide | a diterpenoid triepoxide derived from the herb Tripterygium wilfordii that is used as a natural medicine in China, activates caspase-3 4-119fold in KB cells, 4-70fold in SCC25 cells, and 7.5-90.5fold in OEC-M1 cells, all cancer cells, within 2 days, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | caspase-3, convergent with a variety of death signals, plays a key role in the induction of apoptosis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
KB cell | - |
Homo sapiens | - |
OECM-1 cell | - |
Homo sapiens | - |
pituitary adenoma cell | - |
Homo sapiens | - |
SCC-25 cell | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
activities in KB, SCC25 and OEC-M1 cells in presence and absence of tripolide | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | caspase-3, convergent with a variety of death signals, plays a key role in the induction of apoptosis | Homo sapiens | ? | - |
? |