Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | ethanol and acetylsalicylic acid induce caspase-3 activation, which is inhibited by taurocholate at low concentrations of 0.00001-0.1 mM | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
taurocholate | at low concentrations of 0.00001-0.1 mM it increases caspase-3 activity, but at larger doses of 0.5-10 mM it reverses stimulation to inhibition. It inhibits the caspase-3 pathway and prevents ethanol-induced caspase-3 activation leading to inhibition of apoptosis, overview | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | enzyme regulation in response to damaging agents like ethanol and acetylsalicylic acid in gastric mucosa, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cell culture | - |
Rattus norvegicus | - |
mucosa | - |
Rattus norvegicus | - |
RGM-1 cell | gastric mucosal cell | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | enzyme regulation in response to damaging agents like ethanol and acetylsalicylic acid in gastric mucosa, overview | Rattus norvegicus | ? | - |
? |