Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cisplatin | with or without pre-treatment with HA14-1 it increases the cleavage of caspase-3 | Homo sapiens | |
paclitaxel | pre-treatment of cells with HA14-1 followed by paclitaxel induces cleavage of pro-caspase-3 to active form | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
carbobenzyloxy-DEVD-fluoromethyl ketone | a caspase-3 inhibitor | Homo sapiens | |
carbobenzyloxy-VAD-fluoromethyl ketone | a pan-caspase inhibitor | Homo sapiens | |
ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate | a BH3 mimetic compound, inhibits activation of procaspase-3 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cytokeratine 18 + H2O | Homo sapiens | caspase-induced cytokeratine 18 cleavage in apoptotic cell populations | ? | - |
? | |
additional information | Homo sapiens | the apoptotic effect of cisplatin is caspase-dependent. Caspase-3 inhibitors prevent HA14-1-induced apoptosis in follicular lymphoma B cells | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | pro-caspase-3 is cleaved and activated to caspase-3, pre-treatment of cells with HA14-1 followed by paclitaxel induces cleavage of pro-caspase-3 to active form | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | - |
Homo sapiens | - |
commercial preparation | procaspase-3 and cleaved caspase-3 | Homo sapiens | - |
follicular lymphoma cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cytokeratine 18 + H2O | - |
Homo sapiens | ? | - |
? | |
cytokeratine 18 + H2O | caspase-induced cytokeratine 18 cleavage in apoptotic cell populations | Homo sapiens | ? | - |
? | |
additional information | the apoptotic effect of cisplatin is caspase-dependent. Caspase-3 inhibitors prevent HA14-1-induced apoptosis in follicular lymphoma B cells | Homo sapiens | ? | - |
? | |
additional information | caspase-3 is an effector caspase | Homo sapiens | ? | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000012 | - |
- |
Homo sapiens | carbobenzyloxy-DEVD-fluoromethyl ketone |