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Literature summary for 3.4.22.55 extracted from
- Caspase-2 permeabilizes the outer mitochondrial membrane and disrupts the binding of cytochrome c to anionic phospholipids (2004), J. Biol. Chem., 279, 49575-49578.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | genotoxic stress | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| wild-type, mutants C303A and D316G are expressed in Escherichia coli | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C303A | catalytically inactive | Homo sapiens |
| D316G | uncleavable | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Homo sapiens | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P42575 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| JURKAT cell | JURKAT T-lymphocyte | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| liposomes + H2O | 22°C | Homo sapiens | permealized liposomes | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| caspase-2 | - |
Homo sapiens |
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