Protein Variants | Comment | Organism |
---|---|---|
L143A | self-processes efficiently at the L(pro)/VP4 cleavage site containing P2 phenylalanine, self-processing at the eIF4GII sequence Asp-Phe-Gly-Arg-Gln-Thr is improved but shows more-extensive aberrant processing | Foot-and-mouth disease virus |
L143M | does not self-process efficiently at the L(pro)/VP4 cleavage site containing P2 phenylalanine | Foot-and-mouth disease virus |
additional information | leader proteinase self-processes inefficiently at the L(pro)/VP4 cleavage site Lys-Leu-Lys-Gly-Ala-Gly when the leucine at position P2 is replaced by phenylalanine: Molecular modeling and energy minimization identifies the L(pro) residue L143 as being responsible for this discrimination | Foot-and-mouth disease virus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Foot-and-mouth disease virus | P03305 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
Leader proteinase | - |
Foot-and-mouth disease virus |
Lpro | - |
Foot-and-mouth disease virus |