Literature summary for 3.4.22.38 extracted from

Balkan, W.; Martinez, A.F.; Fernandez, I.; Rodriguez, M.A.; Pang, M.; Troen, B.R.
Identification of NFAT binding sites that mediate stimulation of cathepsin K promoter activity by RANK ligand (2009), Gene, 446, 90-98.

Search for more literature for 3.4.22.38

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in RAW-264.7 cells	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Synonyms

Synonyms	Comment	Organism
CTSK	-	Rattus norvegicus

Expression

Organism	Comment	Expression
Rattus norvegicus	inhibiting calcineurin or chelation of intracellular Ca2+, prevents the stimulation of CTSK expression by nuclear factor kappaB ligand	down
Rattus norvegicus	CTSK expression is stimulated by nuclear factor kappaB ligand. Both, nuclear factor kappaB ligand treatment and overexpression of nuclear factor of activated T-cells c1 dramatically enhances CTSK promoter activity. Proximal nuclear factor of activated T-cells binding sites play a significant role in the nuclear factor of activated T-cells c1-mediated stimulation of CTSK gene expression by nuclear factor kappaB ligand	up

General Information

General Information	Comment	Organism
physiological function	cathepsin K expression is essential for normal bone resorption	Rattus norvegicus

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Release 2023.1 (January 2023)