Application | Comment | Organism |
---|---|---|
diagnostics | to assess better the biology of CatK activity in vivo, a novel near-infrared fluorescence (NIRF) probe for imaging of CatK is developed | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
atherosclerotic plaque | it is shown by fluorescence microscopy of plaque sections from using human carotid endarterectomy specimens that enzymatically active CatK (positive NIRF signal) localizes primarily in the vicinity of CatK-positive macrophages. Augmented NIRF signal (reflecting CatK activity) colocalizes with disrupted elastin fibers within the media underlying plaques | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the NIRF imaging agent consists of the CatK peptide substrate GHPGGPQGKC-NH2 linked to an activatable fluorogenic polymer. In vitro, CatK produces a 2- to 14fold activation of the agent | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cathepsin K | - |
Homo sapiens |
catK | - |
Homo sapiens |