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Literature summary for 3.4.22.38 extracted from

  • Buehling, F.; Roecken, C.; Brasch, F.; Hartig, R.; Yasuda, Y.; Saftig, P.; Broemme, D.; Welte, T.
    Pivotal role of cathepsin K in lung fibrosis (2004), Am. J. Pathol., 164, 2203-2216.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.38

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information the enzyme is almost exclusively colocalized with Lamp-I, a common lysosomal marker in perinuclear areas and in the protrusion of fibroblasts Homo sapiens
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens cathepsin K plays a pivotal role in lung matrix homeostasis under physiological and pathological conditions ?
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 ?
additional information Mus musculus cathepsin K plays a role in collagen degradation ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
lung fibroblast fibroblasts from patients with lung fibrosis contain more cathepsin K activity than those from normal lungs Homo sapiens
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lung fibroblast primary lung fibroblasts derived from CTSK-/- mice show a decreased collagenolytic activity Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information cathepsin K plays a pivotal role in lung matrix homeostasis under physiological and pathological conditions Homo sapiens ?
-
 ?
additional information cathepsin K plays a role in collagen degradation Mus musculus ?
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 ?

Synonyms

Synonyms Comment Organism
catK
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 Mus musculus
catK
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 Homo sapiens