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Literature summary for 3.4.22.37 extracted from

  • Sroka, A.; Sztukowska, M.; Potempa, J.; Travis, J.; Genco, C.A.
    Degradation of host heme proteins by lysine- and arginine-specific cysteine proteinases (gingipains) of Porphyromonas gingivalis (2001), J. Bacteriol., 183, 5609-5616.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.37

Activating Compound

Activating Compound Comment Organism Structure
L-cysteine activates Porphyromonas gingivalis
additional information human serum minimal medium induces enzyme expression Porphyromonas gingivalis

Inhibitors

Inhibitors Comment Organism Structure
hemoglobin prevents haptoglobin alpha-chain degradation in serum Porphyromonas gingivalis

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Porphyromonas gingivalis
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hemopexin + H2O Porphyromonas gingivalis
-
 hemin + ? products of 23 kDa and 40 kDa in serum ?
hemopexin + H2O Porphyromonas gingivalis A7436
-
 hemin + ? products of 23 kDa and 40 kDa in serum ?
transferrin + H2O Porphyromonas gingivalis slight truncation of the polypeptide chain in serum hemin + ?
-
 ?
transferrin + H2O Porphyromonas gingivalis A7436 slight truncation of the polypeptide chain in serum hemin + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Porphyromonas gingivalis
-
 enzyme forms HRgpA and RgpB
-
Porphyromonas gingivalis A7436
-
 enzyme forms HRgpA and RgpB
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 activity induction in bacterial culture Porphyromonas gingivalis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha chains of haptoglobin + H2O low activity, hemoglobin protects Porphyromonas gingivalis ?
-
 ?
alpha chains of haptoglobin + H2O low activity, hemoglobin protects Porphyromonas gingivalis A7436 ?
-
 ?
hemopexin + H2O
-
 Porphyromonas gingivalis hemin + ? products of 23 kDa and 47 kDa ?
hemopexin + H2O
-
 Porphyromonas gingivalis hemin + ? products of 23 kDa and 40 kDa in serum ?
hemopexin + H2O
-
 Porphyromonas gingivalis A7436 hemin + ? products of 23 kDa and 47 kDa ?
hemopexin + H2O
-
 Porphyromonas gingivalis A7436 hemin + ? products of 23 kDa and 40 kDa in serum ?
N-benzoyl-L-arginine-4-nitroanilide + H2O
-
 Porphyromonas gingivalis N-benzoyl-L-arginine + 4-nitroaniline
-
 ?
transferrin + H2O
-
 Porphyromonas gingivalis hemin + ?
-
 ?
transferrin + H2O slight truncation of the polypeptide chain in serum Porphyromonas gingivalis hemin + ?
-
 ?
transferrin + H2O
-
 Porphyromonas gingivalis A7436 hemin + ?
-
 ?
transferrin + H2O slight truncation of the polypeptide chain in serum Porphyromonas gingivalis A7436 hemin + ?
-
 ?

Synonyms

Synonyms Comment Organism
Arginine-specific cysteine protease
-
 Porphyromonas gingivalis
Arginine-specific gingipain
-
 Porphyromonas gingivalis
HRgpA
-
 Porphyromonas gingivalis
RgpB
-
 Porphyromonas gingivalis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Porphyromonas gingivalis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
 assay at Porphyromonas gingivalis