Inhibitors | Comment | Organism | Structure |
---|---|---|---|
acetyl-YVAD-CHO | caspase-1 specific inhibitor | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
pro-interleukin-18 + H2O | Homo sapiens | - |
mature interleukin-18 + ? | - |
? | |
pro-interleukin-1beta + H2O | Homo sapiens | - |
mature interleukin-1beta + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P29466 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
H273 cell | - |
Homo sapiens | - |
NCI-H1299 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pro-interleukin-18 + H2O | - |
Homo sapiens | mature interleukin-18 + ? | - |
? | |
pro-interleukin-1beta + H2O | - |
Homo sapiens | mature interleukin-1beta + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
apoptosis-related cysteine protease | - |
Homo sapiens |
interleukin 1, beta, convertase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | an approximately 32fold increase in caspase-1 expression is observed in the p53-knockin cell line H273 | up |
General Information | Comment | Organism |
---|---|---|
malfunction | gene silencing of caspase-1 or inhibition of caspase-1 activity leads to reduction in dengue virus-induced apoptosis with minimal effect on virus replication | Homo sapiens |