Inhibitors | Comment | Organism | Structure |
---|---|---|---|
acetyl-DEVD-aldehyde | - |
Homo sapiens | |
acetyl-YVAD-aldehyde | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
pre-interleukin-18 + H2O | Homo sapiens | virus infection by influenza A or Sendai virus induces proteolytic processing of IL-18 in human macrophages via caspase-1 and caspase-3 activation | interleukin-18 + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | inactive 45000 Da proform of caspase-1 is basally expressed in macrophages, virus infection induces the cleavage of procaspase into the mature 20000 Da form | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | inactive 45000 Da proform of caspase-1 is basally expressed in macrophages, virus infection induces the cleavage of procaspase into the mature 20000 Da form | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pre-interleukin-18 + H2O | - |
Homo sapiens | interleukin-18 + ? | - |
? | |
pre-interleukin-18 + H2O | virus infection by influenza A or Sendai virus induces proteolytic processing of IL-18 in human macrophages via caspase-1 and caspase-3 activation | Homo sapiens | interleukin-18 + ? | - |
? |