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Literature summary for 3.4.22.34 extracted from

  • Lee, J.; Bogyo, M.
    Development of near-infrared fluorophore (NIRF)-labeled activity-based probes for in vivo imaging of legumain (2010), Chem. Biol., 5, 233-243.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.34

Cloned(Commentary)

Cloned (Comment) Organism
-
 Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
(3S)-3-[(1-acetyl-L-prolyl)amino]-5-[(2,6-dimethylbenzoyl)oxy]-4-oxopentanoic acid starting structure for development of activity-based probes for in vivo imaging Mus musculus
ethyl (2S,3S)-3-[[2-[[(2S)-1-acetylpyrrolidin-2-yl]carbonyl]-1-(2-amino-2-oxoethyl)hydrazinyl]carbonyl]oxirane-2-carboxylate starting structure for development of activity-based probes for in vivo imaging Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Mus musculus 5764
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzyloxycarbonyl-Ala-Ala-Asn-7-amido-4-methylcoumarin + H2O
-
 Mus musculus benzyloxycarbonyl-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
 ?

Synonyms

Synonyms Comment Organism
Asparaginyl endopeptidase
-
 Mus musculus
legumain
-
 Mus musculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000115
-
 pH 7.4 Mus musculus ethyl (2S,3S)-3-[[2-[[(2S)-1-acetylpyrrolidin-2-yl]carbonyl]-1-(2-amino-2-oxoethyl)hydrazinyl]carbonyl]oxirane-2-carboxylate
0.000704
-
 pH 7.4 Mus musculus (3S)-3-[(1-acetyl-L-prolyl)amino]-5-[(2,6-dimethylbenzoyl)oxy]-4-oxopentanoic acid