Literature summary for 3.4.22.29 extracted from

Badorff, C.; Lee, G.H.; Lamphear, B.J.; Martone, M.E.; Campbell, K.P.; Rhoads, R.E.; Knowlton, K.U.
Enteroviral protease 2A cleaves dystrophin: evidence of cytoskeletal disruption in an acquired cardiomyopathy (1999), Nat. Med., 5, 320-326.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
dystrophin + H2O	coxsackievirus	the protease cleaves dystrophin in coxsackievirus B3-infected myocytes. The cleavage functionally impairs dystrophin	?	-	?

Organism

Organism	UniProt	Comment	Textmining
coxsackievirus	-	coxsackievirus B3, protease 2A	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
dystrophin + H2O	human dystrophin is cleaved between residue 588 and 589 and between residue 2434 and 2435. Rat dystrophin is cleaved between resiue 590 and 591 and between residue 2427 and 2428	coxsackievirus	?	-	?
dystrophin + H2O	the protease cleaves dystrophin in coxsackievirus B3-infected myocytes. The cleavage functionally impairs dystrophin	coxsackievirus	?	-	?

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Release 2023.1 (January 2023)