Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
inactive factor X + H2O | Homo sapiens | activation of blood coagulation factor X | active factor Xa + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MCF-7 cell | breast cancer cell line | Homo sapiens | - |
WM-115 cell | malignant melanoma cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
inactive factor X + H2O | activation of blood coagulation factor X | Homo sapiens | active factor Xa + ? | - |
? |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | arsenic trioxide downregulates cancer procoagulant activity in MCF-7 and WM-115 cell lines in vitro and inhibits the proliferation of MCF-7 and WM-115 cells in vivo. all-trans Retinoic acid (ATRA) downregulates the expression of cancer procoagulant in breast cancer cells. Cancer procoagulant activity assay, overview | down |
General Information | Comment | Organism |
---|---|---|
evolution | cancer procoagulant belongs to cysteine proteinase superfamily | Homo sapiens |
physiological function | cancer procoagulant directly activates blood coagulation factor X in absence of activated factor VII. Cancer procoagulant is described in malignant and fetal, but not in normally differentiated tissues. Cancer procoagulant has proadhesive properties together with factor X-activating activity | Homo sapiens |