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Literature summary for 3.4.21.B6 extracted from

  • Tamir, A.; Gangadharan, A.; Balwani, S.; Tanaka, T.; Patel, U.; Hassan, A.; Benke, S.; Agas, A.; DAgostino, J.; Shin, D.; Yoon, S.; Goy, A.; Pecora, A.; Suh, K.
    The serine protease prostasin (PRSS8) is a potential biomarker for early detection of ovarian cancer (2016), J. Ovarian Res., 9, 20 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine PRSS8 is expressed in ovarian cancer at levels more than 100fold greater than in normal or benign ovarian lesions. Overexpression is found in early stages of ovarian cancer and is maintained in higher stages and grades of ovarian cancer. The PRSS8 overexpression is specific for ovarian cancer and urinary bladder cancer among 18 human cancer types. The majority of ovarian cell lines overexpress PRSS8. Overexpression of prostasin is largely localized to tumor epithelium and is absent in neighboring stroma Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q16651
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Source Tissue

Source Tissue Comment Organism Textmining
CAOV-3 cell
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 Homo sapiens
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ES-2 cell
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 Homo sapiens
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OV-90 cell
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 Homo sapiens
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ovary
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 Homo sapiens
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PA-1 cell
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 Homo sapiens
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SKOV-3 cell
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 Homo sapiens
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SW-626 cell
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 Homo sapiens
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TOV-112D cell
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 Homo sapiens
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