Activating Compound | Comment | Organism | Structure |
---|---|---|---|
NS4A | enhances the activity of NS3 protease in all cleavages via the formation of an NS3/NS4A | Hepacivirus C |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.032 | - |
EDVV-4-aminobutyryl-CSMSY | presence of cofactor | Hepacivirus C | |
0.16 | - |
DEMEECSQHLPYI | presence of cofactor | Hepacivirus C | |
0.27 | - |
EDVV-4-aminobutyryl-CSMSY | absence of cofactor | Hepacivirus C | |
0.805 | - |
DEMEECSQHLPYI | absence of cofactor | Hepacivirus C | |
1.01 | - |
Glu-Asp-Val-Val-4-aminobutyryl-Cys-p-nitroanilide | presence of cofactor | Hepacivirus C | |
1.08 | - |
Glu-Asp-Val-Val-4-aminobutyryl-Cys-p-nitroanilide | absence of cofactor | Hepacivirus C |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Hepacivirus C | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DEMEECSQHLPYI + H2O | - |
Hepacivirus C | DEMEEC + SQHLPYI | - |
? | |
ECTTPCSGSWIRD + H2O | - |
Hepacivirus C | ECTTPC + SGSWIRD | - |
? | |
EDVV-4-aminobutyryl-CSMSY + H2O | - |
Hepacivirus C | EDVV-4-aminobutyryl-C + SMSY | - |
? | |
Glu-Asp-Val-Val-4-aminobutyryl-Cys-p-nitroanilide + H2O | - |
Hepacivirus C | Glu-Asp-Val-Val-4-aminobutyryl-Cys + 4-nitroaniline | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.012 | - |
Glu-Asp-Val-Val-4-aminobutyryl-Cys-p-nitroanilide | absence of cofactor | Hepacivirus C | |
0.05 | - |
DEMEECSQHLPYI | absence of cofactor | Hepacivirus C | |
0.18 | - |
EDVV-4-aminobutyryl-CSMSY | absence of cofactor | Hepacivirus C | |
0.2 | - |
Glu-Asp-Val-Val-4-aminobutyryl-Cys-p-nitroanilide | presence of cofactor | Hepacivirus C | |
0.243 | - |
DEMEECSQHLPYI | presence of cofactor | Hepacivirus C | |
0.6 | - |
EDVV-4-aminobutyryl-CSMSY | presence of cofactor | Hepacivirus C |