Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Hepacivirus C | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
peroxidase GPx8 + H2O | - |
Hepacivirus C | ? | membrane-associated peroxidase GPx8 is a cellular substrate of the hepatitis C virus NS3-4A protease. Cleavage by NS3-4A occurs at Cys11, removing the cytosolic tip of GPx8, and is observed in different experimental systems as well as in liver biopsies from patients with chronic HCV | ? |
General Information | Comment | Organism |
---|---|---|
physiological function | membrane-associated peroxidase GPx8 is a cellular substrate of the hepatitis C virus NS3-4A protease. GPx8 is involved in viral particle production but not in HCV entry or RNA replication | Hepacivirus C |