Activating Compound | Comment | Organism | Structure |
---|---|---|---|
glycerol | - |
Yellow fever virus |
Application | Comment | Organism |
---|---|---|
drug development | characteristics of Yellow fever virus protease are very similar to those reported for dengue and West Nile virus proteases, and suggest that pan-flavivirus NS3 protease drugs may be developed for flaviviral diseases | Yellow fever virus |
Cloned (Comment) | Organism |
---|---|
CF40-gly-NS3pro190 expressed as an N-terminally His-tagged fusion protein in Escherichia coli | Yellow fever virus |
Protein Variants | Comment | Organism |
---|---|---|
S138A | inactive | Yellow fever virus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Aprotinin | - |
Yellow fever virus | |
Bz-Ala-Lys-Arg-Arg-H | - |
Yellow fever virus | |
Bz-Arg-Arg-H | - |
Yellow fever virus | |
Bz-Lys-Arg-Arg-H | - |
Yellow fever virus | |
Bz-Nle-Ala-Arg-Arg-H | - |
Yellow fever virus | |
Bz-Nle-Lys-Ala-Arg-H | - |
Yellow fever virus | |
Bz-Nle-Lys-Arg-Ala-H | - |
Yellow fever virus | |
Bz-Nle-Lys-Arg-Arg-H | - |
Yellow fever virus | |
Bz-Nle-Lys-Arg-Lys-H | - |
Yellow fever virus | |
Bz-Nle-Lys-Arg-Phe-H | - |
Yellow fever virus | |
Bz-Nle-Lys-Lys-Arg-B(OH)2 | - |
Yellow fever virus | |
Bz-Nle-Lys-Lys-Arg-H | - |
Yellow fever virus | |
Bz-Nle-Lys-Phe-Arg-H | - |
Yellow fever virus | |
Bz-Nle-Phe-Arg-Arg-H | - |
Yellow fever virus | |
Bz-Phe-Lys-Arg-Arg-H | - |
Yellow fever virus | |
additional information | the P1 and P2 positions are most important for inhibitor binding, whilst the P3 and P4 positions have much less effect | Yellow fever virus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0146 | - |
Bz-norleucine-lysine-arginine-arginine-AMC | - |
Yellow fever virus | |
0.1422 | - |
Boc-Gly-Arg-Arg-AMC | - |
Yellow fever virus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Yellow fever virus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
on Ni2+ affinity column | Yellow fever virus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Boc-Gly-Arg-Arg-AMC + H2O | - |
Yellow fever virus | ? | - |
? | |
Bz-Nle-Lys-Arg-Arg-AMC + H2O | - |
Yellow fever virus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NS2B/NS3 protease | - |
Yellow fever virus |
NS3 protease | - |
Yellow fever virus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.034 | - |
Boc-Gly-Arg-Arg-AMC | - |
Yellow fever virus | |
0.111 | - |
Bz-norleucine-lysine-arginine-arginine-AMC | - |
Yellow fever virus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.5 | - |
- |
Yellow fever virus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
additional information | NS2B required | Yellow fever virus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00001761 | - |
Aprotinin | - |
Yellow fever virus | |
0.00005 | - |
Bz-Nle-Lys-Lys-Arg-B(OH)2 | - |
Yellow fever virus | |
0.00025 | - |
Bz-Phe-Lys-Arg-Arg-H | - |
Yellow fever virus | |
0.0004 | - |
Bz-Nle-Lys-Arg-Arg-H | - |
Yellow fever virus | |
0.0004 | - |
Bz-Lys-Arg-Arg-H | - |
Yellow fever virus | |
0.00075 | - |
Bz-Ala-Lys-Arg-Arg-H | - |
Yellow fever virus | |
0.00085 | - |
Bz-Arg-Arg-H | - |
Yellow fever virus | |
0.0009 | - |
Bz-Nle-Ala-Arg-Arg-H | - |
Yellow fever virus | |
0.0012 | - |
Bz-Nle-Lys-Lys-Arg-H | - |
Yellow fever virus | |
0.0015 | - |
Bz-Nle-Phe-Arg-Arg-H | - |
Yellow fever virus | |
0.0112 | - |
Bz-Nle-Lys-Arg-Lys-H | - |
Yellow fever virus | |
0.0156 | - |
Bz-Nle-Lys-Phe-Arg-H | - |
Yellow fever virus | |
0.03315 | - |
Bz-Nle-Lys-Arg-Ala-H | - |
Yellow fever virus | |
0.062 | - |
Bz-Nle-Lys-Arg-Phe-H | - |
Yellow fever virus | |
0.125 | - |
Bz-Nle-Lys-Ala-Arg-H | - |
Yellow fever virus |