Inhibitors | Comment | Organism | Structure |
---|---|---|---|
serine protease inhibitor A3N | i.e. serpin A3N or SA3N, an extracellular inhibitor of GrB possessing multiple biological functions, including the attenuaxadtion of muscular dystrophy in mice, neuropathic pain, and GrB-mediated decorin cleavage and rupture. It also induces neuroprotection in vitro and in vivo. Role of GrB inhibitor SA3N on Escherichia coli LPS-induced inflammation in NK-92 cells. SA3N pretreatment prevents the LPS-induced changes in expression levels of GRP78, CHOP, NF-kappaB, and IkappaBalpha proteins. Also SA3N pretreatment prevents the expression and exocytosis of GrB by LPS | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P10144 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
chondrocyte | - |
Homo sapiens | - |
keratinocyte | - |
Homo sapiens | - |
macrophage | - |
Homo sapiens | - |
additional information | granzyme B (GrB) belongs to a family of serine proteases that are expressed in the granules of activated CTLs and NK cells that induce apoptosis. GrB is also expressed in non-lymphoid lineage cells, including chondrocytes, neutroxadphils, keratinocytes, and macrophages | Homo sapiens | - |
natural killer cell | - |
Homo sapiens | - |
neutrophil | - |
Homo sapiens | - |
NK-92 cell | - |
Homo sapiens | - |
T-lymphocyte | cytotoxic T lymphocytes | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
GrB | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | serine protease inhibitor A3N, i.e. serpin A3N or SA3N, an extracellular inhibitor of GrB possessing multiple biological functions, including the attenuaxadtion of muscular dystrophy in mice, neuropathic pain, and GrB-mediated decorin cleavage and rupture. It also induces neuroprotection in vitro and in vivo. Role of GrB inhibitor SA3N on Escherichia coli LPS-induced inflammation in NK-92 cells. SA3N pretreatment prevents the LPS-induced changes in expression levels of GRP78, CHOP, NF-kappaB and IkappaBalpha proteins. Also SA3N pretreatment prevents the expression and exocytosis of GrB by LPS | down |
General Information | Comment | Organism |
---|---|---|
malfunction | inhibition of granzyme B activity blocks inflammation induced by lipopolysaccharide through regulation of endoplasmic reticulum stress signaling in NK92 cells. Inhibition of GrB activity suppresses the changes of NF-kappaB and IkappaBalpha expression levels induced by LPS as part of endoplasmic reticulum stress | Homo sapiens |
physiological function | granzyme B (GrB) is a serine protease that is expressed in the lytic granules of natural killer (NK) cells and cytotoxic T lymphocytes (CTL), it plays a role in target cell apopxadtosis and a non-cytotoxic role in inflammation | Homo sapiens |