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Literature summary for 3.4.21.79 extracted from

  • Tsai, T.; Lin, W.; Yang, S.; Cheng, W.; Cheng, E.; Lee, M.; Chong, K.; Chen, C.
    Granzyme G is expressed in the two-cell stage mouse embryo and is required for the maternal-zygotic transition (2010), BMC Dev. Biol., 10, 88.
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm of 2-cell stage, protein completely disappears by the 16-cell stage Mus musculus 5737
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Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
embryo transcripts of the granzyme G gene are detected at the 2-cell stage, but are absent at the oocyte, 1-cell, 96 hr, and later stages. Spatial expression is confined to the extra-embryonic trophoblasts during the middle implantation stage of the mouse placenta Mus musculus
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General Information

General Information Comment Organism
physiological function antisense morpholino oligonucleotide knock-down leads to arrest of early development at the 2- to 4-cell stages. Only 11.6% of treated embryos overcome 2-cell arrest and develop into 4-cell stage embryos. Embryos exhibited decreased zygotic gene transcription Mus musculus