Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | in the presence of perforin, modest cleavage of the encapsulated PEG-P at large unilamellar vesicles/perforin molar ratio of 1000 at acidic and neutral pH. Granzyme B requires a translocation agent to enter the target cell. Granzyme B readily accesses PEG-P only when a membrane disrupting agent, e.g. TX-100, streptolysin O or perforin, is present | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | granzyme B does not bind membrane phospholipids nor has intrinsic membranolytic properties | Homo sapiens | ? | - |
? | |
PEG-P + H2O | virtually all soluble PEG-P is cleaved in 3 min, suggesting PEG-P is a sensitive indicator of granzyme B activity. The granzyme can not access PEG-P when encapsulated in 1,2-dioleoyl-sn-glycero-3-phosphocholine large unilamellar vesicles | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GrB | - |
Homo sapiens |