Literature summary for 3.4.21.79 extracted from

Strik, M.C.; de Koning, P.J.; Kleijmeer, M.J.; Bladergroen, B.A.; Wolbink, A.M.; Griffith, J.M.; Wouters, D.; Fukuoka, Y.; Schwartz, L.B.; Hack, C.E.; van Ham, S.M.; Kummer, J.A.
Human mast cells produce and release the cytotoxic lymphocyte associated protease granzyme B upon activation (2007), Mol. Immunol., 44, 3462-3472.

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Activating Compound

Activating Compound	Comment	Organism	Structure
A23187	induces granzyme B expression in mast cell lines HMC-1 and LAD2 and cord blood-derived mast cells	Homo sapiens
compound 48/80	induces granzyme B expression in mast cell line LAD2 and cord blood-derived mast cells	Homo sapiens
additional information	mature skin-derived mast cells only produce granzyme B upon IgE-dependent stimulation by FcepsilonRI	Homo sapiens
PMA	stimulates	Homo sapiens
SERPINB9	-	Homo sapiens
Substance P	induces granzyme B expression in mast cell line LAD2 and cord blood-derived mast cells	Homo sapiens

Application

Application	Comment	Organism
additional information	role for granzyme B as mediator in mast cell biology	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	active in cytoplasmic granules, mainly located in the dense core, partially colocalizes with tryptase in granules with both lysosomal and secretory features	Homo sapiens	5737	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
colon	between smooth muscle cells	Homo sapiens	-
mast cell	cord blood- and mature skin-derived mast cells. Majority of lesional mast cells express abundant GrB	Homo sapiens	-
additional information	unstimulted HMC-1 cells and LAD 2 cells show no Grb mRNA and protein, expression upon stimulation with non-physiological stimuli	Homo sapiens	-
skin	around skin appendages	Homo sapiens	-
tonsil	around small vessels	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-Ile-Glu-Thr-Asp-p-nitroanilide + H2O	-	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
cytotoxic lymphocyte-associated protease	-	Homo sapiens
cytotoxic lymphocyte-specific protein	-	Homo sapiens
GrB	-	Homo sapiens

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Release 2023.1 (January 2023)