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Literature summary for 3.4.21.79 extracted from

  • Andrade, F.; Roy, S.; Nicholson, D.; Thornberry, N.; Rosen, A.; Casciola-Rosen, L.
    Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis (1998), Immunity, 8, 451-460.
    View publication on PubMed
Search for more literature for 3.4.21.79

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm cytoplasmic granules of cytotoxic T lymphocytes anf natural killer cells Homo sapiens 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA-PKcs + H2O Homo sapiens directly and efficiently cleaved in vitro and in vivo, abolishes kinase activity ?
-
 ?
pro-caspase-10 + H2O Homo sapiens
-
 ?
-
 ?
pro-mCASP-3 + H2O Homo sapiens
-
 caspase-3 + ?
-
 ?
pro-mCASP-7 + H2O Homo sapiens
-
 caspase-7 + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA-PKcs + H2O directly and efficiently cleaved in vitro and in vivo, abolishes kinase activity Homo sapiens ?
-
 ?
additional information requirement for aspartic acid in the substrate P1 position Homo sapiens ?
-
 ?
NuMA + H2O directly and efficiently cleaved in vitro and in vivo Homo sapiens ?
-
 ?
PARP-PKcs + H2O
-
 Homo sapiens ?
-
 ?
pro-caspase-10 + H2O
-
 Homo sapiens ?
-
 ?
pro-mCASP-3 + H2O
-
 Homo sapiens caspase-3 + ?
-
 ?
pro-mCASP-7 + H2O
-
 Homo sapiens caspase-7 + ?
-
 ?