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Literature summary for 3.4.21.75 extracted from

  • Remacle, A.G.; Rozanov, D.V.; Fugere, M.; Day, R.; Strongin, A.Y.
    Furin regulates the intracellular activation and the uptake rate of cell surface-associated MT1-MMP (2006), Oncogene, 25, 5648-5655.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
membrane-tethered membrane type-1 matrix metallo-proteinase + H2O Homo sapiens furin regulates the intracellular activation and the uptake rate of cell surface-associated MT1-MMP at the surface of cancer cells. Furin and related PCs are the essential components of the specialized cellular machinery that controls the levels of the functionally active, mature, MT1-MMP enzyme on the cell surface to continually support the potency of pericellular proteolysis ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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 recombinant
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
membrane-tethered membrane type-1 matrix metallo-proteinase + H2O furin regulates the intracellular activation and the uptake rate of cell surface-associated MT1-MMP at the surface of cancer cells. Furin and related PCs are the essential components of the specialized cellular machinery that controls the levels of the functionally active, mature, MT1-MMP enzyme on the cell surface to continually support the potency of pericellular proteolysis Homo sapiens ?
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 ?
membrane-tethered membrane type-1 matrix metallo-proteinase + H2O there are two furin cleavage motifs, R89-R-P-R-C93 and R108-R-K-R-Y112 Homo sapiens ?
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