Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alpha2-antiplasmin | - |
Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bone marrow cell | - |
Mus musculus | - |
commercial preparation | - |
Mus musculus | - |
RAW-264.7 cell | - |
Mus musculus | - |
General Information | Comment | Organism |
---|---|---|
physiological function | plasmin stimulates phosphorylation of ERK1/2 and p38 MAPK. Plasminogen/plasmin modulates bone metabolism by regulating the osteoblast and osteoclast function. Exogenous plasmin clearly induces the osteoprotegerin expression in plasminogen-deficient osteoblasts. Plasmin activates JNK, but the inhibition of JNK does not attenuate plasmin-induced osteoprotegerin expression | Mus musculus |