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Literature summary for 3.4.21.69 extracted from
- Activated protein C decreases tumor necrosis factor-related apoptosis-inducing ligand by an EPCR-independent mechanism involving Egr-1/Erk-1/2 activation (2007), Arterioscler. Thromb. Vasc. Biol., 27, 2634-2641.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | the serine protease has antithrombotic and antiinflammatory activities, that play an important role in vascular function, APC inhibits TNF-related apoptosis-inducing ligand expression and secretion and its induction by cell activation, mechanism, overview, APC affects signal transduction by increasing ERK phosphorylation, overview | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| umbilical vein endothelial cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the serine protease has antithrombotic and antiinflammatory activities, that play an important role in vascular function, APC inhibits TNF-related apoptosis-inducing ligand expression and secretion and its induction by cell activation, mechanism, overview, APC affects signal transduction by increasing ERK phosphorylation, overview | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Activated protein C | - |
Homo sapiens |
| APC | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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