Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Phospholipid | + Ca2+, stimulates | Oxyuranus scutellatus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
NaSCN | bovine factor Va restores activity; reduces ability to activate prothrombin but has no effect on amidolytic activity | Oxyuranus scutellatus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.166 | - |
prothrombin | - |
Oxyuranus scutellatus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | + phospholipid, stimulates | Oxyuranus scutellatus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
80000 | - |
x * 110000 + x * 80000 + 2 disulfide-linked polypeptides of MW 30000 (one or both of these contain the active site), Oxyuranus scutellatus, SDS-PAGE after reduction with 2-mercaptoethanol | Oxyuranus scutellatus |
110000 | - |
x * 110000 + x * 80000 + 2 disulfide-linked polypeptides of MW 30000 (one or both of these contain the active site), Oxyuranus scutellatus, SDS-PAGE after reduction with 2-mercaptoethanol | Oxyuranus scutellatus |
300000 | - |
Oxyuranus scutellatus, nondenaturing PAGE | Oxyuranus scutellatus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
prothrombin + H2O | Oxyuranus scutellatus | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
More | - |
similar enzymes from: Pseudonaja textilis textilis, Oxyuranus microlepidotus, Demansia nuchalis affinis | - |
Oxyuranus scutellatus | - |
Taipan snake | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
venom | - |
Oxyuranus scutellatus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Factor Xa-specific substrates + H2O | - |
Oxyuranus scutellatus | ? | - |
? | |
additional information | amidolytic activity | Oxyuranus scutellatus | ? | - |
? | |
prothrombin + H2O | conversion in absence of coagulation factor Va | Oxyuranus scutellatus | thrombin + meizothrombin | - |
? | |
prothrombin + H2O | cleavage of Arg274-Thr275 and Arg323-Ile324 | Oxyuranus scutellatus | thrombin + meizothrombin | - |
? | |
prothrombin + H2O | - |
Oxyuranus scutellatus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 110000 + x * 80000 + 2 disulfide-linked polypeptides of MW 30000 (one or both of these contain the active site), Oxyuranus scutellatus, SDS-PAGE after reduction with 2-mercaptoethanol | Oxyuranus scutellatus |