Protein Variants | Comment | Organism |
---|---|---|
G11V | naturally occuring mutation of factor Xa within the omega-loop of the gamma-carboxyglutamic-rich domain of the ature enzyme, leading to enzyme deficiency and a bleeding phenotype, overview. The mutant factor Xa activity is below 1% of wild-type activity, activation with RVV-X is 4fold less effective in the patient's plasma than in healthy plasma. The patient's phenotype appears to be due to a very low rate of FXG11V activation by TF/FVIIa and FVIIIa/FIXa complexes rather than to FXaG11V activity within prothrombinase, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
prothrombin + H2O | Homo sapiens | - |
thrombin + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Homo sapiens | - |
commercial preparation | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
prothrombin + H2O | - |
Homo sapiens | thrombin + ? | - |
? | |
S2765 + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
factor Xa | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | factor Xa deficiency is a rare inherited autosomal recessive trait, a patient harboring the mutation is affected by a severe bleeding diathesis | Homo sapiens |