Inhibitors | Comment | Organism | Structure |
---|---|---|---|
apixaban | i.e. BMS-562247 or 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5-dihydropyrazolo[5,4-c]pyridine-3-carboxamide. Metabolism, pharmacokinetics and pharmacodynamics of the factor Xa inhibitor apixaban. Oxidative metabolism of radiolabeled apixaban by liver microsomes is approximately 20times faster in rabbits than in rats or humans. Prominant metabolites are O-demethyl apixaban, O-demethyl apixaban glucuronide and O-demethyl apixaban sulfate, metabolic profiles, overview | Oryctolagus cuniculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Oryctolagus cuniculus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Oryctolagus cuniculus | - |
liver | - |
Oryctolagus cuniculus | - |
Synonyms | Comment | Organism |
---|---|---|
factor Xa | - |
Oryctolagus cuniculus |
FXa | - |
Oryctolagus cuniculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Oryctolagus cuniculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.8 | - |
assay at | Oryctolagus cuniculus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00022 | - |
inhibition of FXa activity ex vivo | Oryctolagus cuniculus | apixaban |