Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.6 extracted from

  • Barhoover, M.A.; Orban, T.; Beck, D.O.; Bukys, M.A.; Kalafatis, M.
    Contribution of amino acid region 334-335 from factor Va heavy chain to the catalytic efficiency of prothrombinase (2008), Biochemistry, 47, 6840-6850.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.6

Activating Compound

Activating Compound Comment Organism Structure
Factor Va kcat values of prothrombinase assembled with cofactor factor Va mutants D334K/Y335F or D334A/Y335A is reduced. Prothrombinase assembled with quadruple mutant molecules E323Y/E330Y/D334K/Y335F or E323Y/E330Y/D334A/Y335A displays a second-order rate constant up to 400fold lower than the value obtained with wild-type factor Va Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
 Homo sapiens
-

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
additional information
-
 additional information kcat values of prothrombinase assembled with mutant cofactor factor Va D334K/Y335F or D334A/Y335A is reduced. Prothrombinase assembled with quadruple mutant molecules E323Y/E330Y/D334K/Y335F or E323Y/E330Y/D334A/Y335A displays a second-order rate constant up to 400fold lower than the value obtained with wild-type factor Va Homo sapiens