Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alpha-1-antitrypsin | - |
Mus musculus | |
alpha-2-Antiplasmin | - |
Mus musculus | |
alpha-2-Macroglobulin | - |
Mus musculus | |
antithrombin III | - |
Mus musculus | |
C1 esterase inhibitor | main physiological inhibitor | Mus musculus | |
plasminogen activator inhibitor-1 | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
factor XI + H2O | Mus musculus | - |
factor XIa + ? | - |
? | |
prekallikrein + H2O | Mus musculus | - |
kallikrein + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Mus musculus | - |
liver | the proenzyme is mainly produced in the liver | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
factor XI + H2O | - |
Mus musculus | factor XIa + ? | - |
? | |
prekallikrein + H2O | - |
Mus musculus | kallikrein + ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
heterodimer | 1 * 50000 + 1 * 28000, calculated from amino acid sequence | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
alphaFXIIa | - |
Mus musculus |
factor XIIa | - |
Mus musculus |
FXIIa | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | genetic ablation of the enzyme protects against neuroinflammation, reduces the formation of atherosclerotic lesions in Apoe-deficient mice, improves wound healing, and inhibits postnatal angiogenesis | Mus musculus |
physiological function | the enzyme initiates the intrinsic blood coagulation pathway via activation of factor XI, activates the kallikrein-kinin system leading to the release of bradykinin from high molecular weight kininogen, initiates fibrinolysis via proteinase K-mediated urokinase activation. The enzyme induces the expression of inflammatory mediators, promotes cell proliferation, and enhances the migration of neutrophils and lung fibroblasts | Mus musculus |