Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | neutrophil elastase expression is associated with the activity of resident peritoneal mast cells and macrophages, neutrophil elastase mRNA and protein expression and activity are enhanced significantly in matrix metalloproteinase-9-deficient mice during late stages of zymosan peritonitis | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ONO-5046 | selective NE inhibitor, also known as elastase inhibitor IV | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
leukocyte | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O | - |
Mus musculus | N-methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline | - |
? |
Synonyms | Comment | Organism |
---|---|---|
neutrophil elastase | - |
Mus musculus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0002 | - |
ONO-5046 | - |
Mus musculus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000044 | - |
- |
Mus musculus | ONO-5046 |