Inhibitors | Comment | Organism | Structure |
---|---|---|---|
7-(4-chlorophenylsulfonyl-L-glutamyl)amino-5-methyl-2-iso-propylamino-4H-3,1-benzoxazin-4-one | TEI-5624, strong, highly specific inhibitor, prevents degradation of insoluble elastin by elastase, prevents pulmonary hemorrhage in animal model | Cricetulus griseus | |
7-(4-chlorophenylsulfonyl-L-glutamyl)amino-5-methyl-2-iso-propylamino-4H-3,1-benzoxazin-4-one | TEI-5624, strong, highly specific inhibitor, prevents degradation of insoluble elastin by elastase | Homo sapiens | |
7-(4-chlorophenylsulfonyl-L-lysyl)amino-5-methyl-2-iso-propylamino-4H-3,1-benzoxazin-4-one | TEI-6344, strong, highly specific inhibitor, prevents degradation of insoluble elastin by elastase, prevents pulmonary hemorrhage in animal model | Cricetulus griseus | |
7-(4-chlorophenylsulfonyl-L-lysyl)amino-5-methyl-2-iso-propylamino-4H-3,1-benzoxazin-4-one | TEI-6344, strong, highly specific inhibitor, prevents degradation of insoluble elastin by elastase | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Elastin + H2O | Cricetulus griseus | involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged | ? | protein cleaved at at least one location | ? | |
Elastin + H2O | Homo sapiens | involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged | ? | protein cleaved at at least one location | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cricetulus griseus | - |
with induced pulmonary hemorrhage | - |
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lung | - |
Cricetulus griseus | - |
lung | - |
Homo sapiens | - |
sputum | - |
Cricetulus griseus | - |
sputum | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Elastin + H2O | - |
Cricetulus griseus | ? | - |
? | |
Elastin + H2O | - |
Homo sapiens | ? | - |
? | |
Elastin + H2O | involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged | Cricetulus griseus | ? | protein cleaved at at least one location | ? | |
Elastin + H2O | involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged | Homo sapiens | ? | protein cleaved at at least one location | ? | |
methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O | - |
Cricetulus griseus | methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline | - |
? | |
methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O | - |
Homo sapiens | methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000007 | - |
7-(4-chlorophenylsulfonyl-L-glutamyl)amino-5-methyl-2-iso-propylamino-4H-3,1-benzoxazin-4-one | pH 7.5, 37°C | Cricetulus griseus | |
0.000007 | - |
7-(4-chlorophenylsulfonyl-L-glutamyl)amino-5-methyl-2-iso-propylamino-4H-3,1-benzoxazin-4-one | pH 7.5, 37°C | Homo sapiens | |
0.000016 | - |
7-(4-chlorophenylsulfonyl-L-lysyl)amino-5-methyl-2-iso-propylamino-4H-3,1-benzoxazin-4-one | pH 7.5, 37°C | Cricetulus griseus | |
0.000016 | - |
7-(4-chlorophenylsulfonyl-L-lysyl)amino-5-methyl-2-iso-propylamino-4H-3,1-benzoxazin-4-one | pH 7.5, 37°C | Homo sapiens |