Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | mesothelial cells activate the plasma kallikrein-kinin system during pleural inflammation | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | preplasma kallikrein activation on MeT-5A, NCI-H2052, NCI-H28 and primary murine mesothelial cells is strongly inhibited by 10 mM cysteine, 100 mM bradykinin, 100 mg/ml protamine sulfate and 5 mM novobiocin. Moderate inhibition is observed with 2-mercaptoethanol, 2-aminoethyl benzenesulfonyl fluoride, antipain and leupeptin on most cell lines. Angiotensin II, benzamidine and EDTA do not inhibit activation | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
kininogen + H2O | Homo sapiens | - |
bradykinin + fragments of kininogen | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
pleural fluid | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
kininogen + H2O | - |
Homo sapiens | bradykinin + fragments of kininogen | - |
? |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | the plasma kallikrein amidolytic activity is significantly higher on mesothelial cells treated with malignant pleural effusions than compared to those cultured with benign effusions | up |