Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | activation of prekallikrein to active kallikrein proceeds via hydrolysis of the bond Arg371-Ile372 leading to formation of 2 chains connected via 2 disulfide bonds | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | ependymal cells | Homo sapiens | 5829 | - |
soluble | prekallikrein, plasma | Homo sapiens | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
33000 | - |
x * 88000, prekallikrein, SDS-PAGE, x * 33000, kallikrein light chain, SDS-PAGE, x * 55000, kallikrein heavy chain, SDS-PAGE | Homo sapiens |
55000 | - |
x * 88000, prekallikrein, SDS-PAGE, x * 33000, kallikrein light chain, SDS-PAGE, x * 55000, kallikrein heavy chain, SDS-PAGE | Homo sapiens |
88000 | - |
x * 88000, prekallikrein, SDS-PAGE, x * 33000, kallikrein light chain, SDS-PAGE, x * 55000, kallikrein heavy chain, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
kininogen + H2O | Homo sapiens | enzyme is a cofactor in blood coagulation and modulates inflammation through release of bradykinin | bradykinin + fragment of kininogen | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal gland | prekallikrein expression | Homo sapiens | - |
blood | prekallikrein expression | Homo sapiens | - |
brain | prekallikrein expression | Homo sapiens | - |
brain stem | prekallikrein expression | Homo sapiens | - |
cerebral cortex | prekallikrein expression | Homo sapiens | - |
endothelium | prekallikrein expression | Homo sapiens | - |
ependymal cell | in sections of hypothalamus and spinalcord, prekallikrein expression | Homo sapiens | - |
epithelial cell | prekallikrein expression | Homo sapiens | - |
fibre tract | of pons, hipocampus, and medulla, prekallikrein expression | Homo sapiens | - |
fibroblast | prekallikrein expression | Homo sapiens | - |
heart | prekallikrein expression | Homo sapiens | - |
hepatocyte | prekallikrein | Homo sapiens | - |
hippocampus | some fibre tracts, prekallikrein expression | Homo sapiens | - |
hypothalamus | prekallikrein expression | Homo sapiens | - |
kidney | prekallikrein expression | Homo sapiens | - |
leukocyte | prekellikrein expression | Homo sapiens | - |
liver | prekallikrein, secretion into blood circulation | Homo sapiens | - |
lung | prekallikrein expression | Homo sapiens | - |
medulla oblongata | some fibre tracts, prekallikrein expression | Homo sapiens | - |
midbrain | prekallikrein expression | Homo sapiens | - |
additional information | no expression of prekallikrein in the choroid plexus or the cerebellum | Homo sapiens | - |
neuron | prekallikrein expression | Homo sapiens | - |
pancreas | - |
Homo sapiens | - |
pituitary gland | secretory cells, prekallikrein expression | Homo sapiens | - |
placenta | prekallikrein expression | Homo sapiens | - |
plasma | prekallikrein expression | Homo sapiens | - |
pons | some fibre tracts, prekallikrein expression | Homo sapiens | - |
spinal cord | prekallikrein expression | Homo sapiens | - |
thalamus | prekallikrein expression | Homo sapiens | - |
trachea | prekallikrein expression | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
activity in pancreas and brain | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
kininogen + H2O | - |
Homo sapiens | bradykinin + fragment of kininogen | - |
? | |
kininogen + H2O | enzyme is a cofactor in blood coagulation and modulates inflammation through release of bradykinin | Homo sapiens | bradykinin + fragment of kininogen | - |
ir |
Subunits | Comment | Organism |
---|---|---|
? | x * 88000, prekallikrein, SDS-PAGE, x * 33000, kallikrein light chain, SDS-PAGE, x * 55000, kallikrein heavy chain, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
PK | - |
Homo sapiens |
PPK | i.e. plasma prekallikrein | Homo sapiens |