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Literature summary for 3.4.21.34 extracted from

  • Parthasarathy, N.; Torti, S.V.; Torti, F.M.
    Ferritin binds to light chain of human H-kininogen and inhibits kallikrein-mediated bradykinin release (2002), Biochem. J., 365, 279-286.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.34

Inhibitors

Inhibitors Comment Organism Structure
ferritin high-molecular weight kininogen is a ferritin-binding protein, binding to the modified light chain of activated kininogen. Binding to kininogen retards the release of bradykinin by inhibition of kallikrein, no inhibition with substrates other than kininogen, binding mechanism, inhibition by holo- and apoferritin Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
kininogen + H2O Homo sapiens high molecular weight substrate, serine protease heavy chain of kininogen + light chain of kininogen + bradykinin bradykinin is an inflammatory peptide ir

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-Pro-Phe-Arg-4-nitroanilide + H2O
-
 Homo sapiens D-Pro-Phe-Arg + 4-nitroaniline
-
 ir
kininogen + H2O high molecular weight substrate, serine protease Homo sapiens heavy chain of kininogen + modified light chain of kininogen + bradykinin MW of products: 63 kDa, 45 kDa, and 13 kDa, respectively ?
kininogen + H2O high molecular weight substrate, serine protease Homo sapiens heavy chain of kininogen + light chain of kininogen + bradykinin bradykinin is an inflammatory peptide ir

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22 25 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
 assay at Homo sapiens