Activating Compound | Comment | Organism | Structure |
---|---|---|---|
serum | from human, horse, mouse, rat, rabbit, duck, chicken, goat, calf, turtle and foetal bovine serum, leads to increase of the level of the active two-chain form | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
hepatocyte growth factor activator inhibitor-1 | i.e. HAI-1, binding is reversible and acid labile | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
70000 | - |
1 * 70000 + 1 * 240000, complex purified from milk, SDS-PAGE | Homo sapiens |
80000 | - |
noncomplexed form purified from T47D cells, SDS-PAGE | Homo sapiens |
95000 | - |
complexed with HAI-1, purified from milk, SDS-PAGE | Homo sapiens |
240000 | - |
1 * 70000 + 1 * 240000, complex purified from milk, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | degrades extracellular matrix | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9Y5Y6 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | zymogen is activated by proteolytic cleavage | Homo sapiens |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
184A1N4 cell | nontumorigenic mammary epithelial cells | Homo sapiens | - |
epithelial cell | - |
Homo sapiens | - |
mamma | - |
Homo sapiens | - |
MCF-10A cell | - |
Homo sapiens | - |
milk | - |
Homo sapiens | - |
T47D cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | degrades extracellular matrix | Homo sapiens | ? | - |
? | |
N-tert-butoxy-carbonyl-Gln-Ala-Arg-7-amido-4-methylcoumarin | - |
Homo sapiens | N-tert-butoxy-carbonyl-Gln-Ala-Arg + 7-amino-4-methylcoumarin | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 1 * 70000 + 1 * 240000, complex purified from milk, SDS-PAGE | Homo sapiens |
monomer | 1 * 80000 noncomplexed enzyme from T47D cells, SDS-PAGE | Homo sapiens |