Literature summary for 3.4.21.108 extracted from

Martins, L.M.; Morrison, A.; Klupsch, K.; Fedele, V.; Moisoi, N.; Teismann, P.; Abuin, A.; Grau, E.; Geppert, M.; Livi, G.P.; Creasy, C.L.; Martin, A.; Hargreaves, I.; Heales, S.J.; Okada, H.; Brandner, S.; Schulz, J.B.; Mak, T.; Downward, J.
Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice (2004), Mol. Cell. Biol., 24, 9848-9862.

Search for more literature for 3.4.21.108

Application

Application	Comment	Organism
medicine	HtrA2 knockout mice display features characteristic of a Parkinson syndrome, deletion of HtrA2 results in increased susceptibility to cell death stimuli, Smac/DIABOLO can compensate for the removal of HtrA2 in terms of neutralizing inhibitor of apoptosis proteins	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	HtrA2 knockout mice with general decrease in organ size and neurological abnormalities, deletion of HtrA2 results in a mitochondrial dysfunction, death of these mice ca. 30 days after birth	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Mus musculus	5737	-
mitochondrion	HtrA2 in the intermembrane space of healthy cells, density of mitochondria decreased and showed abnormal forms in knockout mice	Mus musculus	5739	-

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Mus musculus	-
embryonic stem cell	-	Mus musculus	-
MEF cell	-	Mus musculus	-
neuron	primary neurons	Mus musculus	-
thalamus	-	Mus musculus	-
thymocyte	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
HtrA2/Omi	-	Mus musculus
serine protease	-	Mus musculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2026.1 (March 2026)