Activating Compound | Comment | Organism | Structure |
---|---|---|---|
H-ficolin | - |
Homo sapiens | |
L-ficolin | - |
Homo sapiens | |
M-ficolin | - |
Homo sapiens | |
mannan-binding lectin | - |
Homo sapiens | |
additional information | MASP-2 is activated by the cleavage of the 76-kDa polypeptide chain into a 52-kDa A chain and a 31-kDa B chain | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
D120G | when D120G is mixed with mannan-binding lectin, no activation of complement component C4 is observed | Homo sapiens |
H155R | the mutant cleaves complement component C4 slightly better than the wild type MASP-2 | Homo sapiens |
additional information | when the mutant enzyme 156_159dupCHNH (CHNHdup) is mixed with mannan-binding lectin, no activation of complement component C4 is observed | Homo sapiens |
P126L | the mutant cleaves complement component C4 with an activity comparable to wild type MASP-2 | Homo sapiens |
R439H | the mutant is deficient in cleavage of complement component C4 despite its normal binding to mannan-binding lectin, the mutant is not able to autoactivate in the presence of mannan-binding lectin and mannan | Homo sapiens |
R99Q | the mutant cleaves complement component C4 with an activity comparable to wild type MASP-2 | Homo sapiens |
V377A | the mutant cleaves complement component C4 with an activity comparable to wild type MASP-2 | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
76000 | - |
SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Homo sapiens | - |
HEK-293 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
complement component C4 + H2O | - |
Homo sapiens | complement component C4b + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MASP-2 | - |
Homo sapiens |
MBL-associated serine protease 2 | - |
Homo sapiens |